The RAF–MEK–ERK signaling pathway plays a central role in cancer development and progression and represents an important target for anticancer drug discovery. Simultaneous targeting of components of this pathway may therefore represent a promising strategy for cancer treatment. A quantitative structure-activity relatio...
M. Er-rajy, Mohamed El Fadili, Hanane Etabti et al.· Frontiers in Bioinformatics· 0 citations
Plant-derived cannabinoids exhibit remarkable structural diversity and have attracted increasing attention as bioactive compounds. Recent in silico studies have explored how these compounds interact with molecular targets involved in neurodegenerative, metabolic, oncological, and viral diseases. This review summarizes...
H. Nour, N. Mounadi, S. Chtita· Mini-Reviews in Medical Chem...· 0 citations
New derivatives based on benzofuran and pyrazole scaffolds designed and assessed for their antioxidant potential and acetylcholinesterase inhibitory activity provide further evidence for the potential of the designed compounds to behave as multi-target ligands with AChE inhibition and antioxidant properties that would...
Mohamed El Fadili, M. Er-rajy, S. Mujwar et al.· Frontiers in Chemistry· 0 citations
Viral respiratory infections still exist as a major global health concern. Influenza A viruses and human metapneumoviruses are among the main pathogens responsible for infections that can progress to severe acute respiratory forms. Despite the availability of certain therapeutic options, the need for effective treatmen...
N. Mounadi, H. Nour, M. el Kouali et al.· PLoS ONE· 0 citations
This study investigates the potential of cannabis-derived compounds to inhibit cyclin-dependent kinase 2 (CDK2), a crucial regulator of cell-cycle progression and colorectal cancer cell proliferation.
Khadija Khaddam Allah, Khaoula Mkhayar, Rachid Haloui et al.· Journal of Genetic Engineeri...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
