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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

S. Costantino

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4 papers indexed here

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Open access Oct 2026

Early life stress induces transgenerational, age-dependent cardiac dysfunction through epigenetic activation of BMP10

Early life stress (ELS) in childhood due to physical or sexual violence, parental neglect, or trauma has been recently associated with an increased risk of cardiovascular disease in later life. However, the mechanisms linking ELS to cardiovascular impairment remain unexplored. To investigate whether ELS in...

P. Enz, S. Mohammed, M. Telesca et al. · 0 citations
Open access Oct 2026

Immune–metabolic crosstalk between T cells and interstitial macrophages drives pulmonary vascular remodeling in cardiometabolic HFpEF

Pulmonary hypertension (PH) is a common and prognostically adverse complication in obese patients with heart failure with preserved ejection fraction (HFpEF). Cardiometabolic HFpEF-associated PH (PH-cHFpEF) is characterized by inflammation and metabolic dysregulation. Alterations in pulmonary immune cell populati...

V. Masciovecchio, M. Telesca, I. Papadopoulou et al. · 0 citations
Open access Oct 2026

Nuclear receptor co-repressor 1 regulates macrophage-driven inflammation in heart failure with preserved ejection fraction via the NLRP3-IL1b pathway: a translational study

Inflammatory response is a key player in heart failure with preserved ejection fraction (HFpEF) but the underlying mechanisms are poorly understood. Recent studies have shown that macrophages are active players in the myocardium and their activation may lead to pathological cardiac remodeling. to investiga...

E. Gorica, L. Di Venanzio, I. Papadopolou et al. · 0 citations
Open access Oct 2026

Paracrine fibroblast–endothelial dialogue promotes pulmonary vascular remodeling in cardiometabolic HFpEF

Pulmonary hypertension (PH) is a common complication of heart failure with preserved ejection fraction (HFpEF) and is associated with worse outcomes than HFpEF alone. Beyond hemodynamic stress, maladaptive remodeling of the lung microenvironment driven by dysfunctional cellular populations may promote pulmonary m...

M. Telesca, V. Masciovecchio, I. Papadopoulou et al. · 0 citations

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