Open access
Sep 2026
Biomechanical stress unmasks a fibroblast-dependent hypercontractile-disarray phenotype in MYBPC3 truncation HCM
Hypertrophic cardiomyopathy (HCM) is commonly caused by pathogenic variants in the sarcomere, such as truncations in myosin-binding protein C (MYBPC3), yet clinical severity and adverse outcomes correlate poorly with genotype alone and are strongly influenced by fibrosis. We developed an engineered human micro-heart ti...
Huan-Zhu Jiang, Ganesh Malayath, Nongmaithem Debeni Devi et al.
· APL Bioengineering · 0 citations