S. D. Thuong

Multi-tiered in silico evaluation identifies Sarsasapogenin as a promising ERα-targeted phytochemical against breast cancer.

Sarsasapogenin, a spirostanol sapogenin with reported activity against ERα-positive breast cancer cells, has no defined molecular target, and its metabolic fate has not been considered in computational studies of this compound class. Network pharmacology, biotransformation profiling, and multi-level molecular modeling...