The immune tumor microenvironment (iTME) plays a crucial role in disease biology of plasma cell (PC) dyscrasias, but remains poorly characterized in self-identified Black individuals, a population at increased risk. Mass cytometry and scRNA-seq of 128 bone marrow aspirates revealed significant changes in immune cell co...
Hong-Wei Tang, William C. Pilcher, Hui-Huang Yan et al.· Blood· 0 citations
OBJECTIVE
ANA indirect immunofluorescence (IIF) is the reference standard but depends on subjective pattern interpretation. We tested whether artificial intelligence (AI) applied to ANA IIF images could identify specific autoantibodies.
METHODS
We assembled a cohort of ANA-positive patients (HEp-2 IIF titer ≥1:80) wi...
Patrick M. Vanderboom, S. Dasari, Marlon J. Sandino-Bermúdez et al.· Arthritis & Rheumatology· 0 citations
Findings establish malignant differentiation state as a causal determinant of immune architecture across GC-derived lymphomas and identify lineage-directed immune reprogramming as a potential therapeutic strategy.
P. Mondello, A. Sadekova, ksenia fede et al.· Research Square· 0 citations
Oxidative phosphorylation (OXPHOS) is a central function and a key indicator of mitochondrial fitness, yet studies in human tissue remain limited. Inclusion body myositis (IBM) is a progressive myopathy that lies at the intersection of aging, inflammation and mitochondrial dysfunction. We aimed to perform a comprehensi...
Ibrahim Shammas, Hazem Iaali, J. Watzlawik et al.· Brain : a journal of neurolo...· 0 citations
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