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Author

S. de Jonghe

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Open access Aug 2026

Imidazole-based tetrachloridoferrate(iii) magnetic ionic liquids: structural insights, photosensitizing potential, and selective anti-glioblastoma activity

Tetrachloridoferrate-based ionic liquids represent an emerging class of functional materials with promising magnetic and biological properties, yet their potential as photosensitizers and anticancer agents remains underexplored. We report the synthesis of new imidazole-based tetrachloridoferrate(iii) salts and a compre...

E. Stingaci, Natalia Sucman, Mariana Neamțu et al. · 0 citations
Aug 2026

Discovery of pyridine formyl hydrazide derivatives as potent non-nucleoside RSV polymerase inhibitors.

Respiratory syncytial virus (RSV) is an RNA virus that infects both the upper and lower respiratory tract and is recognized as a major respiratory health threat. In this study, guided by the cryo-EM structure of the MRK-1-RSV polymerase complex, the substituent region at the C4 position of the shared pyridine core was...

Xin Li, Jinyuan Wu, Lin Zheng et al. · 0 citations
Open access Sep 2026

High-affinity ELR+ CXC chemokines display balanced G protein-, GRK- and β-arrestin-associated transducer engagement at the viral G protein-coupled receptor ORF74

Open reading frame 74 (ORF74) is the single G protein-coupled receptor (GPCR) encoded in the genome of Kaposi’s sarcoma-associated herpesvirus (KSHV). Due to its high constitutive activity and broad chemokine binding profile, ORF74 contributes to KSHV-associated diseases through autocrine and paracrine mechanisms tha...

Qian-Qian Kong, Brent Van Bosstraeten, S. de Jonghe et al. · 0 citations
Open access Aug 2026

Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve

Among the newly synthesized scaffolds, the isothiazolo[3,4-b]pyrazines were the most promising, displaying potent and selective PIKfyve inhibition in a biochemical assay, and, in addition, showing antiviral activity against SARS-CoV-2 (in the low μM range).

Ling-Jie Gao, M. Froeyen, Chieh-Wen Lo et al. · 0 citations
Open access Sep 2026

Repurposing Thiazole/Benzothiazole-Based Thiazolidinone Derivatives as SARS-CoV-2 Main Protease (Mpro) Inhibitors: An Integrated Computational and Experimental Study

Background/Objectives: SARS-CoV-2, the causative agent of COVID-19, relies on its main protease (Mpro) for viral replication, making this enzyme an attractive target for antiviral drug development. In the present study, we investigated whether a library of previously synthesized thiazole/benzothiazole-based thiazolidin...

A. Petrou, Aliki Papadimitriou-Tsantarliotou, Hathaichanok Chuntakaruk et al. · 0 citations
Open access Aug 2026

Chemoproteomics identifies a pyrimido[4,5-d]pyrimidine analogue as a tubulin-tyrosine ligase binder

This work serendipitously identified CEM198 as the first high-affinity ligand of tubulin-tyrosine ligase (TTL), introducing CEM198 as a chemical probe for investigating the tubulin tyrosination–detyrosination and demonstrating the potential of chemoproteomics to uncover novel modulators of microtubule dynamics.

Rubaba R. Abanti, Eleftheria A. Georgiou, D. Makarov et al. · 0 citations

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