S. Deeks

The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy

Significance The persistence of HIV in CD4+ T cells during antiretroviral therapy (ART) remains a barrier to cure. To study this reservoir, we developed an open-source DAb-seq platform that sequences proviral DNA and surface epitopes in single cells and profiled ~527,000 CD4 T cells from individuals on ART. HIV-infecte...

A mechanistic basis for CD8+ T cell expansion sensitivity as a predictor of HIV post-treatment control

A key goal in HIV-1 cure research is to understand why some individuals control viral rebound after stopping antiretroviral therapy (ART). Recent human studies have identified responding CD8+ T cells expressing Ki-67 and the transcription factor TCF-1 as correlates of post-treatment control, but the mechanistic basis o...

Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID

CD4 Count and CD4/CD8 Ratio Impact Antibody Responses to COVID-19 mRNA Booster Vaccination in People with HIV on Suppressive ART.

OBJECTIVE To evaluate the durability of SARS-CoV-2-specific humoral and cellular immune responses after booster vaccination in people living with HIV (PLWH) in a prospective longitudinal cohort study. METHODS We analyzed 46 PLWH with no prior history of SARS-CoV-2 infection who received a booster dose. Anti-receptor-...

HIV DNA and transcription before and after ART in natural controllers compared to noncontrollers

ABSTRACT HIV-1 natural controllers can limit plasma HIV RNA levels in the absence of antiretroviral therapy (ART). Although controllers have less HIV DNA, it remains unclear how HIV transcription differs from noncontrollers, and whether ART further reduces HIV DNA or RNA in controllers. To address these questions, we q...