Author

S. DeWolf

2 papers indexed here

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Open access Nov 2026

An information-theoretic framework for inferring T cell dynamics from single-cell RNA and T cell receptor sequencing.

Single-cell T cell receptor (TCR) repertoire sequencing enables simultaneous profiling of gene expression and TCR sequences, providing a coregistered measure of T cell phenotypic diversity and clonal dynamics. However, principled probabilistic frameworks for joint modeling of clonotype and phenotype have remained limit...

N. Ceglia, Sohrab Salehi, Z. Sethna et al. · Nature Genetics · 0 citations

Open access Oct 2026

Graft-versus-host disease prophylaxis shapes T cell biology and immune reconstitution after hematopoietic cell transplant.

It was determined that PT-Cy-mediated T cell depletion also depleted pathogen-specific TCRs, rendering PT-Cy patients more likely to lack detectable graft-derived pathogen-specific TCRs early after transplant, which was associated with an increased risk of severe infection.

S. DeWolf, S. Siegel, Joseph Schmalz et al. · Science Translational Medici... · 0 citations