Author

S. Dimmeler

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Open access Aug 2026

Mutation-resolved single-cell transcriptomics reveals enhanced β-amyloid clearance in TET2-mutant human monocytes

TET2 silencing in human monocytes and macrophages recapitulated this phenotype and enhanced β-amyloid uptake, indicating mutation-specific bias of innate immunity toward aggregate clearance.

Xiao Yang, Sameen Fatima, Salvador Sampere-Birlanga et al. · JCI Insight · 1 citation

Open access Sep 2026

The periphery of nuclear speckles defines a spatially and temporally regulated compartment of long-lived intron-retained RNAs that resolves during mitosis

RNA localization adds a fundamental layer to gene expression by determining when and where translation-ready mRNAs become available, yet how this timing is coordinated with nuclear architecture and cell-cycle progression remains unclear. Here we identify a subnuclear RNA niche at the nuclear speckle periphery that coup...

Josep Biayna, A. Baranovskii, Anusha Chaudhuri et al. · Nature Cell Biology · 0 citations