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Open access Sep 2026

ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesis and fatty acid oxidation in colorectal cancer

Metabolic reprogramming is a hallmark of cancer cells, and stem-like populations often upregulate aldehyde dehydrogenases (ALDHs). Functional studies have established essential roles for individual ALDH isoforms in tumor initiation, progression, and metastasis; however, the mechanisms by which these enzymes promote mal...

Zhi-Ping Feng, Thomas E. Bearrood, Sydney L. Campbell et al. · 0 citations
Open access Sep 2026

High-throughput spheroid profiling reveals BMP-driven rewiring of glioma cell death responses

The mechanisms regulating glioma cell death are poorly understood. Here, we developed a high-throughput method to study cell death in patient-derived glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG) spheroids. Using this method, we systematically profiled how extracellular ligands modulate compound-induce...

W. Lee, Jennifer J. Salinas, Aastha Gautam et al. · 0 citations

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