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Author

S. Donegà

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2 papers indexed here

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Open access Sep 2026

RNA splicing isoform alterations in muscle mitochondrial membranes of peripheral artery disease patients

Stress-induced metabolic reprogramming is thought to be paralleled by a reorganization of splicing programs, favoring alternative over canonical mRNA isoforms. In peripheral artery disease (PAD), lower extremity muscles are exposed to hypoxia and episodes of ischemia-reperfusion. These conditions may induce cellu...

Ahmed Ismaeel, J. Candia, S. Donegà et al. · 0 citations
Review Open access Sep 2026

Sarcopenia as a manifestation of systemic energetic failure with ageing.

Sarcopenia remains underdiagnosed and undertreated, partly because it continues to be mainly conceptualised as a disorder intrinsic to skeletal muscle. Although current definitions incorporate muscle strength and physical performance, they are not intended to explain the integrated physiological processes that underlie...

Luigi Ferrucci, S. Donegà, A. Picca et al. · 0 citations

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