Author

Ş. Erdem

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Case report Sep 2026

Clinical and immunological characterization of a child with a homozygous TBK1 kinase-domain truncation

The functional consequences of a TBK1-variant bearing a truncation in exon 4 and 5 in a patient with poly arthritis resembling juvenile idiopathic arthritis and necrotizing encephalitis are characterized and may provide insight into the management of immune dysregulation in affected patients.

Büşra Şeniz Demir, S. Çiçek, M. Houran et al. · Immunologic research · 0 citations

Case report Aug 2026

A novel FLNA p.Pro2469Ser variant is associated with impaired T and NK cell function and immune dysregulation

Findings indicate that the FLNA p.Pro2469Ser variant identified in a pediatric patient presenting with recurrent infections and inflammatory manifestations is associated with altered immune-cell signaling, disturbed cortical cytoskeletal organization, and immune dysregulation.

Ş. Erdem, A. Kısaarslan, M. B. Acar et al. · Immunologic research · 0 citations

Aug 2026

Pediatric cystic fibrosis is associated with type 3 immune response

Pediatric CF is associated with selective alterations in circulating type 3 and regulatory immune responses, characterized by increased IL-22-producing lymphocyte populations, reduced plasma IL-17 A concentrations, and increased numbers of CD3⁺IL-10⁺ cells.

Tugba Nur Gur, Z. B. Azizoğlu, Yesim Haliloğlu et al. · Molecular Biology Reports · 0 citations