Author

S. F. P. Braga

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Open access Oct 2026

Drug repurposing-inspired design of miconazole-based 1,2,3-triazoles as antichagasic agents.

Drug-repurposing strategies have been widely explored to accelerate the development of new treatments for Chagas disease, leveraging compounds with previously established safety profiles. Among these, azole antifungals have attracted attention due to their inhibitory activity against 14-α-lanosterol demethylase (CYP51)...

Mariana Araújo Marques, Augusto Vieira Pontes Silva, R. C. F. M. Reis et al. · Bioorganic & Medicinal Chemi... · 0 citations

Open access Sep 2026

Eugenol‐Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights

Findings identify D7 as a promising antiviral lead compound and provide a foundation for further mechanistic, optimization, and in vivo studies aimed at developing anti‐alphavirus therapeutics.

A. C. C. Reis, Amália Luíza de Sousa da Silva, Camila Portruneli et al. · Journal of Medical Virology · 0 citations

Open access Jul 2026

Integrated Computational and Experimental Discovery of Antitumoral Peptides Targeting Luminal A and Triple-Negative Breast Cancer

The combined computational and experimental approach enabled the identification of peptides with selective cytotoxic effects and favorable predicted immunogenic profiles, demonstrating that integrating computational screening with experimental validation is an effective strategy for accelerating the discovery of select...

Isabella Fagundes Gurgel, Ana Carolini Almeida Marcarini, Carlos Marchiorio Lacerda et al. · International Journal of Pep... · 0 citations