Review
Open access
Aug 2026
Targeting ADAR1 in Cancer: Biology, Therapeutic Strategies, Challenges, and Limitations
The emerging landscape of ADAR1 modulators is reviewed, organizing reported compounds into mechanistic classes including nucleoside analogs, catalytic inhibitors, Zα domain modulators, RNA substrate engagement inhibitors, indirect pathway regulators, and PROTACs and molecules within these classes are evaluated with a f...
Carolyn N. Ashley, Emmanuel Broni, Chanyah M. Wood et al.
· Pharmaceuticals · 0 citations