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S. Farhan

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Open access Sep 2026

ARPP21 defines a TDP-43-independent aggregation pathway in amyotrophic lateral sclerosis

Currently, pathological inclusions of ubiquitinated TDP-43 are considered central to the pathogenesis of amyotrophic lateral sclerosis (ALS). However, this view has yielded sparse attention to covert alternative pathways of aggregation in the disease. Here, we identified a pathological axis independent of TDP-43 led by...

D. Campos-Melo, A. Dilliott, S. Farhan et al. · 0 citations

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