Pancreatic Ductal Adenocarcinoma (PDAC) has a tumor microenvironment (TME) that is rich in organized strands of type I collagen. The most commonly used PDAC models utilize basement membrane extract (BME, e.g. Matrigel), which instead contains the more pliable type IV collagen. We hypothesize that utilizing a high...
Marc Abou Assali, Nguyen-Ta Kim, Sural K. Ranamukhaarachchi et al.· Cancer Research· 0 citations
YAP is a central regulator of cell fate, proliferation, and tissue homeostasis that integrates physical cues from the extracellular matrix (ECM). While stiff environments canonically drive YAP nuclear localization and soft environments promote cytoplasmic sequestration, the logic by which cells integrate mechanical inp...
Julian M. Jimenez, B. N. Narasimhan, Zi-Hou Ye et al.· Acta Biomaterialia· 0 citations
Single cells confined by the extracellular matrix can exhibit rotational motion, yet the physical mechanisms underlying its onset and persistence remain unclear. Here, we address this gap with a cellular phase field model that couples cell deformation, cell polarization governed by stochastic excitable dynamics, and co...
S. Echeverría-Alar, B. N. Narasimhan, S. Fraley et al.· Proceedings of the National...· 0 citations
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