Author

S. Fröhling

3 papers indexed here

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Preprint Aug 2026

DNA Methylation Profiling in Melanoma: From Lesion Classification to Therapeutic Stratification

DNA methylation provides a stable record of cellular identity, capturing epigenetic programs that distinguish specialized cell states despite a shared genome. Because malignant transformation and tumour progression are accompanied by extensive epigenetic remodeling, we hypothesized that the methylome of melanocytic les...

J. Winterstein, L. Heinlein, G. Raddatz et al. · 0 citations

Open access Sep 2026

Minigene-based characterization and classification of splice-associated variants in succinate dehydrogenase B

It is demonstrated that targeted sequencing of minigene-derived transcripts provides a scalable approach to evaluate splice-associated SDHB variants and improve variant classification.

Anni Köhler, A. Baumann, N. Lewis et al. · npj Precision Oncology · 0 citations

Open access Aug 2026

Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment.

TFiT (tumor-reactive features in T cells), a transcriptional classifier that identifies tumor-reactive T cells and stratifies immunotherapy, but not chemotherapy, response across independent MM and AML cohorts, supporting its specificity for T cell-mediated tumor control.

N. Kehl, T. Wagner, Simon Steiger et al. · Cancer Cell · 1 citation