S. Galderisi

Longitudinal White Matter Microstructure and Transition to Psychosis in Individuals at Clinical High Risk

Altered white matter microstructure, commonly indexed by fractional anisotropy (FA), has been reported in individuals at clinical high-risk of psychosis (CHR-P) across multiple white matter tracts. However, the relationship between these alterations and later transition to psychosis remains unclear. To address this gap...

in patients with schizophrenia and its associations with negative symptoms and cognition

Defining and operationalizing negative symptom constructs in schizophrenia: A practical guide for clinicians, researchers, and industry stakeholders.

Negative symptoms (NS) are a core dimension of schizophrenia and a major determinant of real-life functioning. The National Institute of Mental Health-Measurement and Treatment Research to Improve Cognition in Schizophrenia (NIMH-MATRICS) initiative and the European Psychiatric Association (EPA) guidance have refined N...