Author

S. Haake

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Open access Sep 2026

41 Clinical Utility of Ultrasensitive ctDNA Detection Across the Renal Cell Carcinoma Disease Spectrum: A Multi-Cohort Retrospective Study

Abstract Background Circulating tumor DNA (ctDNA) is an emerging tool for non-invasive disease monitoring in solid tumor oncology, yet its clinical utility in renal cell carcinoma (RCC) remains poorly defined. RCC exhibits variable ctDNA shedding rates, which may limit assay sensitivity particularly in low-burden disea...

Ezra Blumenthal, Paulo Siqueira Do Amaral, Yi Chen et al. · The Oncologist · 0 citations

Open access Sep 2026

13 Molecular and Clinical Characterization of Early-Onset Renal Cell Carcinoma (eoRCC): A Real-World Multi-Omics Analysis

This analysis compares somatic, germline, immune, transcriptomic, and clinical features of eoRCC vs. typical-onset RCC (toRCC) using a multi-omic real-world dataset and reveals upregulation of hypoxia- and VEGFR-signaling pathways in early-onset ccRCC.

H. Ebrahimi, S. Haake, M. Weitz et al. · The Oncologist · 0 citations

Open access Sep 2026

69 Spatial Proteomics Profiling Identifies Prognostic Biomarkers in Papillary Renal Cell Carcinoma

Abstract Background Papillary renal cell carcinoma (pRCC) is the second most common histology of kidney cancer diagnosed in adults. However, the biologic drivers of recurrence after nephrectomy remain poorly defined, and no molecular biomarkers are routinely used in clinical practice to estimate prognosis. The primary...

W. J. Brewer, Joseph A. Vento, Ezra Blumenthal et al. · The Oncologist · 0 citations