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S. Haque

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Open access Sep 2026

Preclinical mechanistic study of rotundic acid against cyclophosphamide-induced nephrotoxicity in Swiss albino mice through modulation of oxidative stress, inflammation, apoptosis, and fibrosis via NF-κB/Caspase-3/TGF-β1 Pathways.

Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical utility is limited by severe adverse effects, including nephrotoxicity. Therefore, the present study investigated the nephroprotective potential of rotundic acid (RA) against CP-induced renal toxicity in mice. RA is a natural pentacycl...

Mohammad Moonis, Divya Vohora, S. Haque · 0 citations

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