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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

S. Henikoff

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2 papers indexed here

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Review Open access Sep 2026

Hypertranscription: the invisible hand in cancer epigenetics

Global upregulation of transcription, or hypertranscription, is observed in most human cancers, driven by the action of oncogene-encoded transcription factors (TFs). TF interactions with RNA Polymerase II (Pol II) are mediated by kinases that phosphorylate the Pol II C-terminal domain (CTD) to drive productive elonga...

S. Henikoff, Robert N. Eisenman, K. Ahmad · 0 citations
Open access Aug 2026

BAF perturbation heightens cancer cell dependence on CDK12-driven transcription elongation by RNA polymerase II

CDK12 facilitates transcriptional elongation and processivity by RNA polymerase II (Pol II). Although it has emerged as a promising actor and target in cancer, better understanding of CDK12 gene transcription control could inform the design of novel anti-cancer strategies. Here, we identify a co-dependency between CDK1...

Monika Mačáková, Cassidy Danyko, Stefan Oberlin et al. · 0 citations

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