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Author

S. Hensley

2 papers indexed here

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Open access Jul 2026

Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells.

Marginal zone (MZ) B cells optimize protection against blood-borne bacteria by rapidly producing plasma cells in response to Toll-like receptor (TLR) ligands. Here, we demonstrate that Notch2 instructs this responsiveness for both the dsRNA sensor TLR3 and LPS sensor TLR4. Using mathematical modeling of cell trace time...

Jennifer Londregan, Isaiah Rozich, Brian T. Gaudette et al. · 0 citations
Open access Aug 2026

Potent type-specific de novo antibodies complement broadly reactive imprinted antibodies in immune responses to SARS-CoV-2 variants

Hundreds of recall and de novo neutralizing monoclonal antibodies are isolated and characterized after sequential exposures to SARS-CoV-2 variants in ancestral-imprinted humans to reveal the distinct contributions of recall and de novo antibodies to a balanced immune response and underscore the benefit of updated boost...

T. Johnston, Shuk-Hang Li, M. Painter et al. · 2 citations

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