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Open access Sep 2026

Plasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults.

Chronic inflammation is a common feature of aging and is observed across various age-related neurodegenerative diseases, including Alzheimer's disease (AD). Diffusion magnetic resonance imaging (dMRI) metrics of white matter microstructure are hypothesized to be sensitive to inflammation, though few studies have assess...

Siona Mishra, C. Pettigrew, Chidi Ugonna et al. · 0 citations
Open access Sep 2026

Association of plasma biomarkers with longitudinal change in age- and Alzheimer’s disease-related brain atrophy patterns

Among CU individuals, plasma p-tau217 was associated with subsequent MCI/dementia due to AD and showed the most extensive associations with longitudinal AD-related brain atrophy, compared with SPARE-BA or R-indices capturing subcortical, diffuse cortical, or perisylvian atrophy.

Murat Bilgel, Ishaan Shah, Jasmine M. Cooper et al. · 0 citations

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