Open access
Aug 2026
High-throughput screening in hiPSC-cardiac models reveals cardiomyocyte-specific cell cycle regulatory mechanisms
A dual-reporter and a high-throughput image-based pipeline are developed and a cardiomyocyte-selective pro-proliferative compound is identified as GDC-0339, uncovering cardiomyocyte-specific mechanisms governing the cell cycle that are potentially druggable.
Francesca Butera, Bryce Hassett, Rachel Morris et al.
· bioRxiv · 0 citations