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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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S. Jacobi

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Open access Sep 2026

Spatial transcriptomics reveal impaired metabolic liver zonation in acute-on-chronic liver failure.

BACKGROUND AND AIMS Extrahepatic organ failures are key determinants of acute-on-chronic liver failure (ACLF). While the role of systemic inflammation and mitochondrial dysfunction in the pathogenesis of ACLF is well known, the contribution of the liver itself is less understood. We therefore performed transcriptome an...

Mona-May Langer, H. Stadler, M. Mannewitz et al. · 0 citations

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