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S. Jaffrey

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Open access Aug 2026

m6A pathway suppression reprograms gene expression during the integrated stress response

This study identifies the direct coordination of translation suppression and transcriptome reprogramming through m6A during the ISR, and shows that mRNA stabilization, not transcription activation, explains much of the transcriptome response during the ISR.

Shino Murakami, S. Jaffrey · 0 citations