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Author

S. Jayasundara

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Jul 2026

Sp1 links CD46 to CD4 T cell metabolic fitness, survival, and retroviral control.

It is shown that the CD46 signaling domain cytoplasmic tail 1 (CYT-1) engages the transcription factor Sp1 in human CD4 T cells to dynamically modulate Sp1-DNA interactions, defining a human-specific transcriptional mechanism linking complement signaling to metabolic adaptation, apoptosis regulation, and antiviral defe...

Parul Singh, Luopin Wang, Pavitra Ramdas et al. · 0 citations
Open access Jul 2026

A distal transcribed enhancer of KRAS fine-tunes Tfh-mediated vaccine response 2308711

A systematic catalog of eRNAs in human adaptive immune cells is defined and a distal transcribed enhancer is identified that fine-tunes KRAS signaling in Tfh cells to support effective vaccine responses, establishing eRNAs as noncoding regulators of T cell circuits controlling antibody production.

Dhaneshwar Kumar, S. Sahoo, B. Yan et al. · 0 citations

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