Author

S. Josefowicz

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Open access Aug 2026

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence

DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence, highlighting the importance of heterochromatin maintenance in preserving adult microglial identity and plasticity, with broader implications for brain homeostasis, healthy aging...

Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al. · Nature Neuroscience · 1 citation

Open access Jul 2026

Inflammatory hematopoiesis drives intestinal inflammation and is modulated by anti-TNF therapy 2309660

HSPCs act as a systemic reservoir of inflammatory memory, while TNF blockade partially restores hematopoietic homeostasis, highlighting progenitor reprogramming as a therapeutic target.

Jin-Gyu Cheong, Chenyang Jiang, Muxue Du et al. · Journal of Immunology · 0 citations

Jul 2026

Mapping the chromatin landscape of the mouse immune system with low-input automated CUT&RUN 2260000

Understanding how immune cells develop and function requires insight into the epigenomic mechanisms that regulate gene expression. While many genomic studies focus on transcriptional outputs, changes in the chromatin landscape play a central role in shaping lineage commitment. The mammalian immune system is compo...

Aaron J. Alcala, M. Marunde, C. L. Windham et al. · Journal of Immunology · 0 citations