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S. K. Jha

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Review Open access Sep 2026

Mitochondrial metabolic plasticity in cancer: hybrid bioenergetic states and translational targeting in surgical oncology

Mitochondrial metabolism is increasingly recognized as an active determinant of tumor growth and cancer-cell adaptation rather than solely a source of cellular energy. Mitochondrial metabolism supports tumor anabolism, while mitochondrial DNA (mtDNA) alterations can affect respiratory chain function, redox homeostasis,...

Debdeep Chattopadhyay, R. Rajendran, Nida Mubin et al. · 0 citations
2026

Deciphering the oncogenic role of RRM2 in Glioblastoma multiforme and its modulation by plant derived compounds

Glioblastoma multiforme (GBM) is an extremely virulent and treatment-resistant primary brain tumor that has a very rapid course, is commonly recurrent, and has very poor patient prognosis. Discovery of strong molecular targets is still urgent to further precision oncology in GBM. An integrative bioinformatics and compu...

S. Singh, Pardeep Yadav, S. K. Jha · 0 citations

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