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Open access Aug 2026

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells

Liver cancer incidences increase dramatically beyond 55 years of age, suggesting that age-associated changes contribute critically to tumor initiation. However, the mechanisms linking liver aging and cancer initiation remain incompletely defined. This study investigated the role of CD44, a marker of liver tumor-ini...

Armin Gandhi, Kathryn Lande, K. Li et al. · 0 citations
Jul 2026

Reprogramming of Glioblastoma-Immune Crosstalk to Overcome Immunotherapy Failure 2258791

Glioblastoma multiforme (GBM) is a lethal brain cancer with a median survival of less than a year. Immunotherapies, such as immune checkpoint blockade (ICB), represent promising treatment options but still face challenges due to tumor resilience. Understanding how the brain and tumor environment shape immune resp...

Shuozhi Liu, Lizmarie Garcia-Rivera, Michael A. LaPorta et al. · 0 citations

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