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Open access Sep 2026

Efficacy and safety of thalidomide (1 vs 2 mg/kg/d) in transfusion-dependent thalassemia: A Non-Inferiority Trial.

Thalidomide has emerged as a fetal hemoglobin-inducer with potential to reduce transfusion burden in transfusion-dependent thalassemia (TDT). However, optimal dosing remains undefined A prospective, randomized, open-label, multicentric clinical trial was conducted at four centres in India to compare efficacy and safety...

S. Kakkar, Amita Mahajan, R. Sharma et al. · 1 citation
Review Oct 2026

Future-proofing thalassaemia care: harnessing scalable therapies, artificial intelligence, and global collaboration.

Advances in the treatment of thalassaemia have led to major improvements in survival and quality of life over the past 30 years. In addition to developments in stem-cell transplantation, transfusion safety, iron overload monitoring, and iron-chelation therapy, novel disease-modifying and gene therapies are also emergin...

Hanny T. Al-Samkari, F. Aboobacker, B. Andemariam et al. · 2 citations

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