The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal ageing and its relationship to psychiatr...
Hui Yang, Tereza Clarence, Madeline R. Scott et al.· Nature· 3 citations
Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited1,2. Here, to gain deeper insights into the aetiology of different brain diseases, we used specimens f...
Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse et al.· Nature· 5 citations
Proteomics holds great promise for identifying potentially druggable effectors of common diseases, yet its application at population-scale across diverse ancestries, remains challenging. Here, we developed genetic imputation models for 2,594 plasma proteins using proteomic and genetic data from 54,219 UK Biobank partic...
Yu Xu, Douglas P. Loesch, H. Taylor et al.· medRxiv· 0 citations
Interindividual heterogeneity in Alzheimer’s disease (AD) remains poorly understood, as disparate single-cell studies leave it unclear whether findings reflect shared architecture or dataset-specific idiosyncrasies. Here, we present panAD, a transcriptomic atlas of >3 million nuclei from 791 individuals across 13 studi...
Negin Rahimzadeh, S. Morabito, S. Khullar et al.· bioRxiv· 0 citations
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