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Open access Sep 2026

Test substance preparation determines the tested fraction and the outcome of human health NAMs for poorly-water-soluble (pre)polymers

While a comprehensive revision of the REACh regulation is currently no longer under consideration, regulatory requirements potentially covering analytical, ecotoxicological, and toxicological aspects of polymers may still evolve. Regulatory testing typically relies on OECD test guidelines (TGs), which are generally des...

S. Kolle, Philipp Demuth, N. Hambruch et al. · 1 citation
Review Open access Sep 2026

Scientific perspectives on in vivo developmental neurotoxicity testing: study design, regulatory context, and future directions.

Developmental neurotoxicity (DNT) potential of (agro)chemicals is assessed in rodents according to OECD Test Guidelines (TG) 426 (DNT) or 443 (Extended One-Generation Reproductive Toxicity; EOGRTS) incorporating a DNT cohort. While the EOGRTS evaluates reproductive and neurotoxicity endpoints across multiple life stage...

P. Coder, Richard P. Lewis, Anika Christoffel et al. · 0 citations

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