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S. Kuo

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Open access Oct 2026

Aziridination-Based Crosslinking Enables Site-Resolved Elucidation of Lipid Binding and Protein Conformational Changes

Lipid–protein interactions play critical roles in cellular function, yet their site-resolved characterization remains challenging due to the dynamic nature of lipid binding and the limited availability of chemoselective strategies for covalently capturing native lipid–protein contacts. Here, we introduce aziridinatio...

Chia-Lung Tsai, A. Tasnim, Zhen-Yu Xi et al. · 0 citations
Open access Aug 2026

Solution Phase Protein Dynamics: Influences of ESI Buffers on Hydration

Buffers are commonly selected for their compatibility with biochemical measurements or their specific capabilities, yet buffer interactions with proteins and the surrounding water can actively reshape protein activity, structure, and dynamics. Here, we compare the influences of three widely used electrospray ionization...

Emily Burningham, Carter Lantz, R. Rider et al. · 0 citations

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