Author

S. L. la Fleur

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Open access Sep 2026

Voluntary physical activity modulates brain ΔFOSB and alters co-activation networks in male and female mice.

Regular physical activity promotes brain health, yet the underlying mechanisms remain incompletely understood. Repetitive activation of neurons results in accumulation of the nuclear transcription factor ΔFOSB, a long-lived splice variant of FOSB. Long-term voluntary wheel running (VWR), a behavioral paradigm that mimi...

Marene H. Hardonk, Rick Wenning, J. Stofberg et al. · eNeuro · 0 citations

Open access Aug 2026

Activation of D2-Expressing Medium Spiny Neurons in the Nucleus Accumbens Core Mirrors the Delaying Effect of Novelty Exposure on Feeding Onset in Rats

These findings suggest that NAcc D2-MSNs are recruited under conditions of environmental novelty to modulate feeding-related decision-making, and may impair behavioral flexibility and contribute to maladaptive feeding patterns, with implications for the neurobiology of eating disorders.

A. S. V. van Irsen, Tess Kool, Salimat Semenova et al. · Journal of Neuroscience · 0 citations