Tandem-Affinity Crosslinking Mass Spectrometry Supports a Model of a DNA-PKcs-PP6 Regulatory Complex.
Protein complexes can be modeled with data arising from crosslinking mass spectrometry, but it is difficult to collect such data from cellular sources, particularly for proteins that are part of extensive interaction networks. Here, we present a tandem-affinity purification crosslinking mass spectrometry (xTAP‑MS) meth...