The phosphate exporter XPR1 promotes gasdermin D–independent mature IL-1β secretion
Interleukin (IL)-1β is a leaderless inflammatory cytokine that is not secreted via the classical endoplasmic reticulum-Golgi pathway. Instead, mature IL-1β secretion is classically associated with pyroptosis, a caspase-dependent inflammatory cell death mediated by gasdermin D (GSDMD) pore formation at the plasma membra...