BACKGROUND
Although commonly accepted depressive subtypes reflect phenotypic differences, there has been minimal progress in identification of discrete pathophysiological pathways, biomarkers or differential therapeutic approaches to effectively guide clinical management.
AIMS
To test the biological validity and clin...
E. Tonini, J. Crouse, M. Shin et al.· The British journal of psych...· 1 citation
In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
CRD-load was associated with clinical symptoms, functional impairment, and mood-related genetic liability, and these findings support further evaluation of brief assessments of circadian-associated phenotypes for identifying young people at greater clinical burden and informing circadian-focused prevention and early in...
M. Shin, E. Tonini, J. Carpenter et al.· medRxiv· 0 citations
Internalising symptoms including depression, anxiety and somatic symptoms in adolescence are common. They can be transient, but they can also persist and progress to major depressive disorder (MDD) Polygenic risk scores for major depression (MD-PGS) may help identify which symptomatic adolescents are at greatest risk o...
E. Byrne, Nathan A. Gillespie, J. Najman et al.· Molecular Psychiatry· 0 citations
Summary Paragraph Personality traits describe stable differences in how people think, feel, and behave and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, generalizability,...
T. Schwaba, Margaret L. Clapp Sullivan, W. Akingbuwa et al.· Nature· 5 citations· ⚡1
Little is known about how stigma is perceived within psychiatric genetics, a field increasingly central to public discussions about heredity, neurodiversity, and psychiatric risk. Understanding how stigma is perceived and experienced by psychiatric geneticists is important for guiding responsible communication and futu...
A. Thijssen, E. Tissink, R. Sud et al.· American Journal of Medical...· 0 citations
Findings show that the directionality of neurovegetative symptoms indexes genetic heterogeneity within MDD, with metabolic biology as a central axis of differentiation.
A. Harder, Rujia Wang, Jacob Bergstedt et al.· medRxiv· 0 citations
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