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Author

S. Mitrofanov

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Open access Aug 2026

Insights from GWAS, TWAS, and DEG analysis: CDKN2B-AS1, MAP3K4, and P2RX2-encoded P2X2 receptor identified as potential therapeutic targets for ischemic heart disease in Russian adults and long-living individuals

Background The purpose of this study was to investigate genetic risk factors associated with ischemic heart disease (IHD) in Russian adults, to develop prognostic PRS models for IHD risk stratification, and to gain a better understanding of molecular mechanisms underlying IHD through a transcriptome analysis. Materials...

Veronika Daniel, Наталья Георгиевна Романова, A. Mamchur et al. · 0 citations
Open access Jul 2026

Congenital heart defects genetic architecture in a small cohort: an integrated approach to prioritizing variants

This study expands the understanding of the genetic landscape underlying congenital heart anomalies and emphasises the need for larger, deeply phenotyped cohorts to translate preliminary insights into clinically applicable predictors.

A. Korobeinikova, E. Petriaikina, D. Tychinin et al. · 0 citations

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