Author

S. Miyagawa

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Review Open access Sep 2026

Complement system in kidney transplantation: from innate immune surveillance to a therapeutic and genetic engineering target

Kidney transplantation remains the most effective treatment for end-stage kidney disease; however, long-term graft survival is constrained by rejection and chronic graft injury, and donor shortages continue to drive interest in xenotransplantation. The complement system is increasingly recognized both as a terminal eff...

Y. Kakuta, Shuji Miyagawa, Shunsuke Mori et al. · Frontiers in Immunology · 0 citations

Open access Oct 2026

Evaluation of desmosome dynamics using iPS cell-derived cardiomyocytes identifies neddylation inhibitor as a modifier of relaxation in arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is a hereditary disease caused by desmosomal haploinsufficiency and associated with heart failure and sudden cardiac death. Disease-modifying therapies targeting the underlying molecular mechanisms remain limited. Isogenic-induced pluripotent stem cell–derived cardiomyocytes...

Cong-Cong Sun, Hiroyuki Inoue, Shuichiro Higo et al. · Stem Cell Research & The... · 0 citations

Open access Aug 2026

Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation.

BACKGROUND Diastolic dysfunction is a recognized chronic allograft complication, and a restrictive left ventricular filling pattern is associated with adverse outcomes. However, the underlying pathophysiological mechanisms remain unclear. METHODS AND RESULTS This study included 32 heart transplant recipients with a n...

Kosuke Takahari, Tatsuya Shiraki, H. Kioka et al. · Circulation Journal · 0 citations