Author

S. Mostafavi

2 papers indexed here

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Open access Sep 2026

A Gene-Program Architecture of Mouse T cells

We present a gene-program framework for resolving mouse T cell heterogeneity across the immgenT atlas. On ∼800,000 T cells spanning lineages, organs, and immune challenges, we defined 200 reproducible gene programs, discovered by empirical Bayes matrix factorization approach and validated through a new deep learning ap...

Ziang Zhang, Tian-Ze Wang, Siba Smarak Panigrahi et al. · bioRxiv · 0 citations

#artificial intelligence Preprint Sep 2026

Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Many biological discovery problems require experiments to be selected sequentially under constrained budgets. CRISPR screening is a prominent example, as exhaustive perturbation testing is often infeasible and candidate perturbations must instead be prioritized over multiple experimental rounds. Despite the importance...

Carl N. Edwards, E. De Brouwer, Xiner Li et al. · 0 citations