Author

S. Mukhambetzhanov

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Open access Sep 2026

Clinically Relevant Pharmacogenomic Variant Frequencies in Kazakh, Russian, and Uzbek Population Groups Residing in Kazakhstan

Simple Summary Central Asian populations remain poorly represented in pharmacogenomic research, limiting the availability of population-specific information for precision medicine. In this study, we analyzed 112 directly genotyped, clinically relevant pharmacogenomic variants in 1301 Kazakh, Russian, and Uzbek individu...

Zhassulan Zhaniyazov, Akmaral Kulatayeva, Aikorkem Mustafayeva et al. · Biology · 0 citations

Open access Sep 2026

Adaptive Grid Generation by Solving the Two-Dimensional Diffusion Equation Using Physics-Informed Neural Networks

Adaptive computational grids improve the accuracy and efficiency of numerical simulations by concentrating nodes in regions of particular interest, but classical adaptation methods based on differential equations are often computationally expensive and geometry-dependent. This study proposes a physics-informed neural n...

O. Turar, M. Mustafin, S. Mukhambetzhanov et al. · Algorithms · 0 citations

Open access Sep 2026

Physics-Informed Neural Networks for Coupled Non-Isothermal Two-Phase Flow in Porous Media: Training Pathologies, Remedies, and the Role of Gradient Conflict

Physics-informed neural networks (PINNs) are difficult to train on strongly coupled, multi-objective systems: with fixed loss weights an otherwise identical run succeeds or diverges with the random seed, and a leading explanation attributes the failures to conflict between the loss-term gradients. We test that explanat...

Y. Kenzhebek, T. Imankulov, S. D. Bekele et al. · Machine Learning and Knowled... · 0 citations