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Author

S. Naismith

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Open access Oct 2026

Plasma metabolomic profiling of frailty in older adults at risk of dementia

Background: Frailty is a prominent risk factor for dementia. Early detection of at-risk individuals may enable intervention to prevent or slow dementia pathology. Blood-based biomarker discovery could offer a path for early detection of frailty and cognitive decline. Methods: Older adults at risk of dementia underwent...

I. Alldritt, J. Michaelian, R. Yu et al. · 0 citations
Open access Sep 2026

A Double-Blind Randomised Controlled Crossover Trial of the Effect of Blue-Enriched Ambient Light on Sleep in Older Adults With Sleep Disturbance: The CleverLights Study.

Light interventions have been investigated for treating sleep disturbances in older adults; however, findings are mixed. This proof-of-concept trial investigated the effect of blue-enriched ambient light on electroencephalographic (EEG) sleep in older adults with self-reported poor sleep. Twelve participants (65.6 ± 8....

T. Pun, Craig L. Phillips, Nathaniel S. Marshall et al. · 0 citations
Open access Oct 2026

REM sleep EEG slowing signals basal forebrain integrity in older adults with subjective and mild cognitive impairment

Introduction The basal forebrain is an early site of pathology in Alzheimer's disease (AD). Within this region, the nucleus basalis of Meynert (NbM) provides the primary cholinergic input to the neocortex and supports cortical activation during rapid eye movement (REM) sleep. REM electroencephalography (EEG) slowing is...

A. Lam, N. Espinosa, E. Matar et al. · 0 citations
Review Open access Sep 2026

Night-Time Heat Stress, Ageing and Neurodegeneration - The Next HOT Topic

A “hotter nights–sleep disruption–neurodegeneration” pathway is proposed as a plausible framework for future research, and management implications, including targeted sleep and heat advice, medication review, caregiver planning and cooling strategies are outlined.

S. Kong, Federico Tartarini, Yorgi Mavros et al. · 0 citations
Open access Aug 2026

Sleep spindles are linked to white matter connectivity differentially in older adults with and without cognitive impairment

Overall, white matter connectivity of the anterior thalamic radiation and superior longitudinal fasciculus was not robustly associated with sleep spindle density or slow oscillatory power in this at-risk cohort, but superior longitudinal fasciculus II connectivity may differentially relate to spindle amplitude in mild...

A. Lam, S. Kong, J. Palmer et al. · 0 citations

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