Author

S. Nattel

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Open access Sep 2026

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearanc...

Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo et al. · Experimental Physiology · 0 citations

Open access Sep 2026

Resistance to atrial fibrillation domestication and mitochondrial dysfunction in sheep: a potential key role of the TCA cycle and mitochondrial redox state

Background Atrial fibrillation (AF) often progresses from paroxysmal to more stable forms. It is well-recognized that patients vary in their AF progression, but the underlying mechanisms remain unclear. This work, performed in a sheep AF-model, aimed to identify atrial redox and energetic status differences between ani...

G. Caluori, S. Nattel, Benoît Pinson et al. · Redox Biology · 0 citations

Open access Aug 2026

Pacemaker-implantation and atrioventricular-node ablation vs pulmonary vein isolation for elderly patients with persistent atrial fibrillation: the ABLATE versus PACE trial.

BACKGROUND AND AIMS Population aging is increasing atrial fibrillation (AF) prevalence. In elderly patients with persistent AF, pulmonary-vein isolation (PVI) has limited success, but is widely used. Pacemaker-implantation with atrioventricular-node ablation (PM+AVNA) provides effective symptom control, but the relativ...

A. Boehmer, Lars Eckardt, M. Rothe et al. · European Heart Journal · 0 citations