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Author

S. O'Connor

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Open access Jul 2026

Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like state and insights into progression.

Four astrocytoma cell lines derived from IDH-mutant astrocytomas are established and extensively characterized and evidence that NOTCH signaling contributes to the regulation of cell state balance, promoting transitions toward an astrocyte-like transcriptional program while DLL3, an anti-Notch protein, expressed by oli...

L. Garcia, C. Granotier-Beckers, D. Pineau et al. · 0 citations
Open access Jul 2026

Resolving Immune Lineage and Cell-State Heterogeneity in Human PBMCs via Mass Spectrometry-Based Single-Cell Proteomics

This work developed an integrated experimental and computational pipeline for protein-level cell annotation and applied it to human PBMCs as an immune-cell test case, delivering an analytically benchmarked SCP workflow that resolves immune lineage and cell-state heterogeneity in human PBMCs and provides a classifier-re...

S. O'Connor, Romell B. Gletten, Ritin Sharma et al. · 1 citation

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