S. O’Sullivan

α-Synuclein impairs mitochondrial function and alters cryptochrome regulation in the substantia nigra

Data provide evidence of a specific window of time during which sustained α-synuclein burden results in direct α-synuclein-mitochondria interactions and nigral mitochondrial damage and a specific remodeling of molecular clock components occurs, providing a potential new mechanism contributing to metabolic and mitochond...