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Author

S. Ovchinnikov

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Open access Sep 2026

Proteome-wide crosslinking mass spectrometry reveals novel components of essential complexes in Toxoplasma

A high-coverage crosslinking mass spectrometry framework is developed to map the proteome-wide interactome of the model apicomplexan parasite Toxoplasma gondii and identifies and validated previously unrecognized components of essential protein complexes, including a structurally distinct ATP synthase subcomplex contai...

S. Butterworth, Ashley L. Gin, Shikha Shikha et al. · 0 citations
Open access Aug 2026

Learning millisecond protein dynamics from what is missing in NMR spectra.

Key dynamics directly linked to biological function, including enzyme catalysis and ligand binding, are particularly well predicted by Dyna-1, which parallels the findings that residues experiencing µs-ms exchange are more conserved.

Hannah K. Wayment-Steele, Gina El Nesr, Ramith Hettiarachchi et al. · 1 citation
Open access Jul 2026

Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer.

Multiple sequence alignment (MSA) Pairformer is presented, a protein language model that builds on AlphaFold2/3's bidirectional refinement between sequence and pairwise residue representations to accurately model the evolution of protein-protein interactions, despite training exclusively on individual chains.

Yo Akiyama, Zhidian Zhang, Olivia Tang et al. · 3 citations

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