Author

S. Ozaki

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Open access Sep 2026

Robust helicase loading mechanism underlies diverse architectures of bacterial replication origins

These findings reveal remarkable architectural flexibility, mechanistic robustness, and a conserved mechanism in oriC, and highlight unwinding stability as a key determinant of oriC adaptation to rapid cell growth, providing insight into the evolution of oriC architecture.

Ryusei Yoshida, Kazutoshi Kasho, S. Ozaki et al. · Nucleic Acids Research · 0 citations

Open access Sep 2026

Origin flexibility governs robust ssDNA engagement by the DnaA initiator.

In model bacteria, initiation of chromosome replication requires engagement of single-stranded DNA by oligomers of the DnaA-family initiator assembled within the origin DNA. Although arrays of double-strand motifs recognized by DnaA are a general feature of the origins, the DnaA-binding single-strand elements are eluci...

Nanato Kiyohara, Yasutaka Wakasugi, Kohei Ihara et al. · Proceedings of the National... · 0 citations