Some novel benzimidazole and benzoxazole methyl ester derivatives as BCL2 inhibitors and BAX activators: Synthesis, anticancer activity and in silico evaluation.
Discovering novel anticancer drugs with high efficacy and minimal toxicity is of great importance in anticancer drug research and development. Apoptosis is a critical regulatory mechanism in cancer progression mediated by BCL2 family proteins and BAX, which together play a key role in the regulation of programmed cell...