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Author

S. P. Rosshart

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Open access Aug 2026

The microbiome determines the phenotype in CTLA-4 insufficient mice and men

CTLA-4 (haplo)insufficiency displays incomplete penetrance and phenotypic heterogeneity, indicating the involvement of additional disease modifiers beyond the genetic defect. Microbiome analyses reveal a positive association between disease severity and intestinal dysbiosis, highlighting the microbiome as a critical co...

Bei Zhao, Lara Stopp, Pavaret Sivapornnukul et al. · 0 citations
Open access Aug 2026

Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota

The mouse epidermis harbors two key resident immune populations—dendritic epidermal T cells (DETCs), a subset of invariant γδ T cells, and Langerhans cells (LCs), specialized tissue-resident macrophages—both of which play critical roles in immune surveillance, barrier integrity, and tissue homeostasis. While their feta...

D. Obwegs, Alexander Oschwald, L. Koetter et al. · 0 citations

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